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Checkpoint : DNA Damage Checkpoint
S. cerevisiae S.pombe Human Mw (kD) Chromosome Structure and Function Description
RAD9 crb2 BRCA1??     BRCT domain homologous to Brca1 and 53BP1
RAD24 rad17 Hrad17   4q13.3-21.2 RF-C related homologous to RF-C, interacts with Hrad1
RAD17 rad1 Hrad1 282a.a. 5p13.2-13.3 3'-5' exonuclease homologous to Ustilago maydis Rec1
MEC3         GTPase?  
MEC1/ESR1 rad3 ATR     protein kinase homologous to PI3 kinase
TEL1   ATM   11q23 protein kinase homologous to PI3 kinase
RAD53/SPK1/MEC2/SAD1 cds1 Chk2   22q11 protein kinase multicopy suppressor of pol alpha mut
Dun1   Chk2     protein kinase  
    C-TAK1     protein kinase Cdc25C associated protein kinase
CHK1? chk1 Chk1   11q24 protein kinase  
POL2 cdc20 Pol epsilon catalylic subunit   12q24.3 DNA polymerase  
DPB11 cut5/rad4?       BRCT domain multicopy suppressor of dpb2
RFC5 . RFC38?     RF-C  
DDC1 rad9 Hrad9   11p13.1-13.2    
BMH1, BNH2? rad24. rad25 14-3-3     14-3-3  
- Hus1 Hus1Hs   7p13-p12   associated with rad1p and rad9p
  rad26