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CDCs : S. cerevisiae
S. cerevisiae S. pombe Human Xenopus Drosophila Description
CDC1         protein that affects bud emergence, intrachromosomal recombination
CDC2/POL3   DNA pol delta catalytic subunit     DNA polymerase delta
CDC3         GTPase (septin family), defective in cytokinesis
CDC4         component of SCF, WD40-repeat/F-boxhomologous to G protein β subunit
CDC5/PKX2 plo1 PLK (polo like kinase)   polo protein kinase
CDC6 cdc18 CDC6Hs     involved in initiation of DNA replication
CDC7 Hsk1 cdc7Hs xcdc7   protein kinase
CDC8         Thymidylate kinase
CDC9   DNA ligase I, 102kD     DNA ligase
CDC10         GTPase (septin family), defective in cytokinesis
CDC11         GTPase (septin family), defective in cytokinesis
CDC12         GTPase (septin family), defective in cytokinesis
CDC13         binds to single-stranded TG1-3 telomere G-tails
CDC14         soluble tyrosine-specific protein phosphatase
CDC15         protein kinase
CDC16 Cut9 APC6/Cdc16Hs APC6 (75-78kD)   component of APC, tetratrico peptide repeat, spindle fiber
CDC17/POL1   DNA polymerase alpha       DNA pol alpha catalytic subunit
CDC18         cdc5ts like phenotype
CDC19/PYK1   pyruvate kinase     pyruvate kinase
CDC20 Slp1       WD-repeat, inhibited by interaction with Mad1, 2 and 3
CDC21/TMP1         Thymidylate synthetase
CDC23   APC8Hs APC8 (66-69kD)   component of APC, tetratrico peptide repeat
CDC24/CLS4   cdc24Hs     Ca binding protein, genetic interaction with CDC42
CDC25         Ras-GEP, regulatory protein of adenylate cyclase
CDC27 Nuc2 APC3/Cdc27Hs APC3 (100-130kD)   component of APC, tetratrico peptide repeat, spindle fiber
CDC28 cdc2 cdc2Hs/cdk1     protein kinase
CDC30         glucose-phosphate isomerase
CDC31         Ca binding protein, involved in replication of spindle pole body
CDC32         some cdc32ts suppress cdc51ts
CDC33         eIF-4E
CDC34/Ubc3         component of SCF, ubiquitinate phosphorylated Cln2 as a E2
CDC35/CYR1         adenylate cyclase, interacts with Ira1
CDC36         required for Start B in mitosis and for meiosis I spindle pole body separation
CDC37         cdc28ts like phenotype
CDC39         required for Start B in mitosis and spindle pole body separation at meiosis I
CDC40         partial DNA replication,
CDC42         Rho subfamily, genetic interaction with CDC24 and CDC43
CDC43         β subunit of prenyltransferase, genetic interaction with CDC42
CDC44   hRFC140, 128kD     DNA pol delta accsessory protein, large subunit of RFC
CDC45   CDC45Hs (22q11.2, 566a.a.)     involved in initiation of DNA replication, genetic interaction with CDC46 and CDC47
CDC46/MCM5 nda4 MCM5/mCDC46 - DmCDC46 member of complex that acts at ARS's to initiate replication
CDC47/MIS1 - MCM7/P1.1 - - essential for initiation of DNA replication
CDC48         homologous to multimeric ATPase
CDC49         small bud and small nuclei
CDC50         small bud and small nuclei
CDC51         large bud and undivided nuclei, suppressed by cdc32ts
CDC53         component of SCF, similar phenotype of cdc4ts and cdc34
CDC54 cdc21 MCM4/mcdc21 Xcdc21 Dpa genetic interaction with cdc46 and cdc47
CDC55         protein phosphatase2A regulatory subunit beta
CDC60         cytosolic leucyl tRNA synthetase
CDC63/RPT1         defective in initiatin of translation
CDC65/DNA33         arrested cell cycle before Start
CDC67         arrested cell cycle before Start
CDC68/SPT16     DUF   suppressed by multicopy of CLN2, interacts with DNA pol alpha
CDC72/NMT1         N-myristoyltransferase
CDC73